Hiki i ka EGCG ke pale i ka ma'i Parkinson a me Alzheimer

Ua kamaʻāina ka hapa nui o ka poʻe i ka maʻi Parkinson a me Alzheimer. ʻO ka maʻi o Parkinson kahi maʻi neurodegenerative maʻamau. He mea maʻamau i ka poʻe ʻelemakule. ʻO ka awelika makahiki o ka hoʻomaka ʻana ma kahi o 60 mau makahiki. ʻO ka poʻe ʻōpio me ka hoʻomaka ʻana o ka maʻi Parkinson ma lalo o ke 40 makahiki he kakaikahi. ʻO ka nui o ka PD ma waena o ka poʻe ma luna o 65 mau makahiki ma Kina ma kahi o 1.7%. ʻO ka hapa nui o nā poʻe maʻi me ka maʻi Parkinson he mau maʻi maʻamau, a ʻoi aku ka liʻiliʻi o 10% o nā maʻi he moʻolelo ʻohana. ʻO ka hoʻololi pathological koʻikoʻi i ka maʻi o Parkinson ʻo ka degeneration a me ka make o nā neurons dopaminergic i ka substantia nigra o ka midbrain. ʻAʻole maopopo ke kumu maoli o kēia loli pathological. ʻO nā kumu genetic, nā mea kaiapuni, ka ʻelemakule, a me ke koʻikoʻi oxidative hiki ke komo i ka degeneration a me ka make o nā neurons PH dopaminergic. ʻO kāna mau hōʻike lapaʻau ka nui o ka haʻalulu hoʻomaha, bradykinesia, myotonia a me ka haʻalulu postural gait, ʻoiai hiki i nā mea maʻi ke hele pū me nā hōʻailona non-motor e like me ke kaumaha, constipation a me ka pilikia hiamoe.

ʻO Dementia, ka mea i kapa ʻia ʻo ka maʻi Alzheimer, kahi maʻi neurodegenerative holomua me kahi hoʻomaka hoʻopunipuni. ʻO ka maʻi maʻi, ua hōʻike ʻia e ka dementia maʻamau, e like me ka hoʻomanaʻo ʻana, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, a me nā loli i ke ʻano a me ka ʻano. ʻO ka poʻe me ka maʻi ma mua o ka makahiki 65 i kapa ʻia ʻo ka maʻi Alzheimer; ʻO ka poʻe me ka hoʻomaka ma hope o ka makahiki 65 i kapa ʻia ʻo Alzheimer.
Hoʻopilikia pinepine kēia mau maʻi ʻelua i ka poʻe ʻelemakule a hopohopo nui i nā keiki. No laila, pehea e pale aku ai i ka hiki ʻana mai o kēia mau maʻi ʻelua, ʻo ia ka ʻimi noiʻi o ka poʻe naʻauao. He ʻāina nui ʻo Kina no ka hana ʻana i ke kī a me ka inu kī. Ma waho aʻe o ka hoʻomaʻemaʻe ʻana i ka aila a me ka hoʻopau ʻana i ka momona, loaʻa ka kī i ka pōmaikaʻi i manaʻo ʻole ʻia, ʻo ia hoʻi, hiki iā ia ke pale i ka maʻi Parkinson a me ka maʻi Alzheimer.
Loaʻa i ke kī ʻōmaʻomaʻo kahi mea hana koʻikoʻi nui: epigallocatechin gallate, ʻo ia ka mea hana ikaika loa i ka polyphenols kī a no nā catechins.

Ua hōʻike ʻia nā haʻawina he nui ka epigallocatechin gallate e pale i nā aʻalolo mai ka pōʻino i nā maʻi neurodegenerative. Ua hōʻike ʻia nā haʻawina epidemiological hou i ka pili ʻana o ka inu kī me ka hiki ʻana mai o kekahi mau maʻi neurodegenerative, no laila ua manaʻo ʻia e hiki i ka inu kī ke hoʻoikaika i kekahi mau hana pale endogenous i nā cell neuronal. Loaʻa i ka EGCG kahi hopena antidepressant, a ʻo kāna hana antidepressant e pili pono ana i ka pilina o nā mea hoʻokipa γ-aminobutyric acid. No ka poʻe i loaʻa i ka maʻi HIV, ʻo ka neurodementia i hoʻokomo ʻia i ka maʻi he ala pathogenic, a ua hōʻike nā haʻawina hou e hiki i ka EGCG ke kāohi i kēia kaʻina hana pathological.
Loaʻa ka EGCG i ke kī ʻōmaʻomaʻo, akā ʻaʻole i ke kī ʻeleʻele, no laila hiki i ke kīʻaha kīʻaha ma hope o ka ʻai ʻana ke hoʻomaʻemaʻe i ka aila a hoʻomaha i ka momona, he olakino maikaʻi. Hiki ke hoʻohana ʻia ka EGCE i unuhi ʻia mai ke kī ʻōmaʻomaʻo i nā huahana olakino a me nā mea hoʻohui meaʻai, a he mea hana maikaʻi loa ia e pale ai i nā maʻi i ʻōlelo ʻia ma luna.